Chloramphenicol
The use of this drug is contraindicated because the use of chloramphenicol will increase the effect of Sildenafil by affecting the patient hepatic and intestinal enzyme metabolism.
Isosorbide dinitrate
The use of this drug is contraindicated because the combination of this drug either increases the effects of the other by vasodilation which leads to fatal hypotension.
Nitroprusside sodium
The use of this drug is contraindicated because the combination of this drug either increases the effects of the others by pharmacodynamic synergism.
Enzalutamide
Use alternative drugs because the use of enzalutamide will decrease the effect of Sildenafil by affecting patient hepatic and intestinal enzyme metabolism.
Acetazolamide
Therapy should be administered with caution because the use of Sildenafil increases the effect of acetazolamide by pharmacodynamic synergism and it also increases the risk of hypotension.
The use of this medicine can lower blood pressure and when combining it with alcohol further increases the effect. You may experience dizziness, lightheadedness, fainting, flushing, headache, and heart palpitation. Also, avoid consuming grapefruit juice because it may increase the effect of avanafil on blood levels.
Cardiovascular disease:
The use of phosphodiesterase-5 enzyme inhibitors is contraindicated in patients with cardiovascular disease. A doctor should consider the vasodilatory effects of this drug and whether they may affect patients with cardiovascular disease. The use of this drug may increase the risk of angina pectoris, AV block, myocardial infarction, ventricular arrhythmia, tachycardia, palpitation, hypotension, postural hypotension, syncope, cerebral thrombosis, cerebrovascular hemorrhage, transient ischemic attack, cardiac arrest, heart failure, and hypertension. These events can occur during or after sexual activity.
Renal dysfunction:
Therapy should be administered with caution in patients with severe renal disease or on renal dialysis. The plasma clearance of this drug is decreased in patients with a severe renal impairment which results in drug accumulation.
Liver diseases:
The use of this drug is not recommended for patients with severe hepatic impairment because the pharmacokinetic disposition of this drug has not been assessed in patients with severe hepatic impairment.
Addictive (IDs or other drugs)The FDA has provided a black box warning for the presence of these drug interactions. The FDA offers a black box warning for the presence of these drug interactions in patients aged 5-44 years. The use of this drug may increase blood pressure and when combined with alcohol further increases the effect.
Interaction(s) physicalxiety/ Depression| Aceclofenac | Alcohol |
You may experience dizziness, lightheadedness, fainting, flushing, headache, dizziness, or fainting.
1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.
2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/
3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf
4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36
5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs
Central Government.https://www.cg-us.gov.in/Content/PRisite/Prisite.aspx in/very/Bigfun-36-published or translated into other sites.https://www.leeford.in/ifestyle/me-and-co[/] Giulia Trasciti and her team have developed a combination of non-tissue transglutaminase (ntTg) inhibitors for the treatment of patients with patients with non-severe forms of non-severe pulmonary arterial hypertension (non-pulmonary hypertension - non-SBN).Bigfun-36 states “Nmt indulge in sildenafil citrate as first-pass effect and as a topical solution to improve patient tolerability.” In its full-oroughfare endorsement, Bigfun-36 recommends that “in most cases, sildenafil is the first-line treatment for patients with non-severe forms of non-severe pulmonary arterial hypertension.” “Nmt will not recommend sildenafil in the treatment of patients with severe forms of pulmonary arterial hypertension (‘pulmonary arterial hypertension’).”
Bigfun-36 has updated the EMC to “in the treatment of patients with severe forms of pulmonary arterial hypertension (“pulmonary arterial hypertension”).” As a result, “In the treatment of severe forms of pulmonary arterial hypertension (‘pulmonary arterial hypertension’), sildenafil should be prescribed with caution in patients with severe pulmonary arterial hypertension (“pulmonary arterial hypertension”).”
Tracy Giddingsen, MD, FRCPC, FRCPCM, FRCPCN, FRCPCP, FRCPCW, FRCPCWN, FRCPCZN, and FRCPCY.https://www.brec.brandshawley.com/product/556/nmt- indulge
Literature search
This article is being shared for additional information about nmt indulge in sildenafil citrate as first-pass effect and as a topical solution to improve patient tolerability.
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Tadalafil andof any drug interaction are classed as
Cialis (tadalafil) tablets are a prescription medication that treat erectile dysfunction (ED). This prescription medication requires a prescription, so you can get rid of the prescription if you have one of the following conditions:Allergies: to prevent the symptoms of an allergy orIRDrection: to keep blood in your penis (hypotension).
A patient can get a prescription for this medication from their doctor if they have allergies to tadalafil or any other ingredients in the prescription.
A prescription is required for Cialis. To get a prescription for Cialis, fill out the online form below and one of our doctors will review your information.
You can then add your prescription to your shopping cart and pay the Cialis price for your order.
Cialis (tadalafil) tablets are a prescription medication for treating erectile dysfunction (ED).
A patient can get a prescription for this medication from their doctor if they have allergies to tadalafil or any other other ingredients in the prescription.
Before we explain how Tadalafil helps manage ED, we need to explain how erections occur naturally. When you become aroused, your body releases a substance called nitric oxide (NO). In turn, levels of a chemical known as cyclic guanosine monophosphate (cGMP) increase in your body, relaxing the muscles on the sides of your penis so blood can flow into the organ and trigger a stiff erection.
While all this is happening, your body also compresses the veins that take blood away from the penis, so that the blood remains in place and you can maintain that erection. Eventually, the PDE5 enzyme in your body gets to work, and it processes the cGMP. When that happens, your erection dissipates, and the penis becomes flaccid once again.
If you have ED, regardless of the underlying cause, this natural process is somehow interrupted. That makes it more difficult for you to get or maintain an erection that’s sufficient for intercourse. And that’s where Tadalafil, a PDE5 inhibitor, can help. By blocking this enzyme in your body, you’ll have an easier time getting an erection and holding on to it until sex is complete.
As we mentioned earlier, ED can be caused by various factors, and when there’s an underlying cause, all of them can contribute to the condition. If you’ve ever been wary of whether or not you’re urinating after taking nitrates, this caution can easily convince you otherwise. And as we’ve already discussed, when you become sexually aroused, your body releases a substance called nitric oxide (NO).
As a result of this increased level of cGMP, your penis becomes flaccid, and you’re able to have an erection that’s sufficient for sex. And since all this blood has been going out and out in response to this stimulation, all of this additional blood has been processed by the PDE5 enzyme, which finally got to work. And that’s it! That’s it! An and you’re ready for sex.
aleb- EverittWhile Tadalafil can be beneficial in treating ED, it’s important to realize that it can also cause a number of side effects.
The most common side effects of Tadalafil include:
aleb-dellIf you’ve ever worried that you’re experiencing any of these side effects while taking nitrates, these may be a sign of a more serious condition. If you experience any of the following symptoms, stop taking Tadalafil and seek medical attention immediately:
aleb-Dell
Stade de France Pharmacy